From Searching the Proteome to Studying Low Temperature Reactivity of Astrochemical Species. A quest Driven by Advanced Ion Optical Systems in Customized Mass Spectrometry and Ion Mobility Instrumentation.

Abstract
Since the discovery of isotopes at the onset of the 20th century mass spectrometry has evolved with a remarkable pace to become a leading analytical tool with an outstanding diversity of applications and instrumentation platforms. Electrospray and matrix assisted laser-desorption ionization where pivotal to expanding the role of mass spectrometry in the field of life sciences. The extraordinary progress in the field of proteomics and most recent developments in the field of microbial identification and clinical diagnostics are all enabled by advancements in mass spectrometry instrumentation. This talk will introduce Fasmatech’s R&D team to the audience through a series of projects highlighting the diverse application areas of research addressed by unique developments in custom engineered solutions combining mass spectrometry and ion mobility instrumentation. Notably are a new separation method based on differential mobility properties of ions at low pressure in laminarized subsonic flows and a unique design of a linear ion trap to provide access to an extensive arsenal of ion activation-dissociation techniques for the comprehensive analysis of proteins in the gas phase.

About the Speaker
Dr. Dimitris Papanastasiou is a co-founder and director R&D at Fasmatech providing customized instrumentation solutions to academic and research institutions across Europe and covering diverse areas of research. He is a leading expert in ion optics, RF ion traps, differential ion mobility spectrometry and time-of-flight mass analyzers. He has been involved in basic research, product R&D and several diverse prototype instrumentation development projects and has been awarded over 10 patent families, authored 10 peer review articles, 1 textbook chapter and conference papers in topics extending from ion-molecule collision theory and time-focusing equations to nanoparticle research, image velocimetry techniques and top-down proteomics.

Dimitris obtained his BSC from the Environmental Science Department at the University of the Aegean in Lesvos, Greece where he focused on scintillation counters for radon monitoring. He holds an MSc and a PhD degree in Time-of-Flight mass spec instrumentation development from Manchester Metropolitan University in the UK. During post-doctoral training in New Mexico State University the focus of his research was on developing differential ion mobility spectrometers coupled to mass spectrometry. Dimitris has also worked at the Shimadzu Research Laboratory (SRL) developing hybrid mass analyzers and he is also the inventor of the low pressure differential mobility spectrometer. In August 2014 he received the Curt Brunnée Award by the International Mass Spectrometry Foundation for outstanding contributions to the development of the theoretical understanding of ion behaviors and implementation of this knowledge in new devices for ion optics and ion mobility. The award was primarily given for the successful demonstration of ion separation based on differential mobility properties of ions in low pressure laminarized subsonic flows.

Dimitris most recent contribution to the field of mass spectrometry is the development of the omnitrap platform, a unique a linear ion trap designed to provide access to an extensive arsenal of ion activation-dissociation techniques for the comprehensive analysis of proteins in the gas phase.

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