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Seminar: Genome-wide Association Studies and Breast Cancer Risk Prediction

Event Details:

  • Date:          Tuesday, 4 October 2022
  • Time:         Starts: 16:00
  • Venue:       Events Room, 1st Floor, Novel Technologies Laboratory (NTL), The Cyprus Institute.
                       This is a hybrid, public event.  You may attend in-person or alternatively, connect to our live stream of the discussion, available on Zoom (Password: VsSCz1)
                       If you would like to attend in-person then please RSVP by Monday 3 October, 13:00
  • Speaker:    Dr Kyriaki Michailidou, Associate Scientist and lead of the Biostatistics Unit, The Cyprus Institute of Neurology and Genetics



CyI Logo RTI ver b     CaSToRC HPC

 

CaSToRC, the HPC National Competence Centre,
 invites you to the EuroCC and SimEA Seminar Series



 

Abstract

Over the last years, Genome-wide Association studies (GWAS) have identified thousands of variants robustly associated with different complex traits. Large scale genotyping and meta-analyses of more than 200,000 breast cancer cases and controls, mainly through the Breast Cancer Association Consortium, led to the identification of 200 loci that are associated with breast cancer susceptibility. The majority of these variants are common in the population (minor allele frequency >5%) and contribute to a small fraction of the disease risk. These variants have shown to combine in a multiplicative way and can be summarized as a polygenic risk score (PRS) that can be used to categorize women into different risk categories and thus has the potential to be used in breast cancer prevention.

In this talk, she will give a brief introduction for GWAS and then focus on discoveries in breast cancer. She will discuss PRS and post GWAS approaches such as fine mapping.

 

About the Speaker

Kyriaki MichailidouDr Michailidou is a statistical genetic epidemiologist with extensive expertise in the analysis of large genetic and genomic datasets. She is currently an Associate Scientist and lead of the Biostatistics Unit at the Cyprus Institute of Neurology and Genetics. She trained in Mathematics (B.Sc., Aristotle University of Thessaloniki), Applied Statistics (M.Sc., University of Oxford) and Genetic Epidemiology (Ph.D., University of Cambridge).

Her research lies in the fields of statistical genetics, epidemiology and genetic epidemiology of diseases with a focus on analysis of common and rare genetic variants identified through Genome-Wide Association Studies (GWAS) and next-generation sequencing experiments. Her research involves the classification of variants of uncertain clinical significance in high-risk genes, fine mapping of loci identified through genome wide scans and Polygenic Risk Scores (PRS).

She has been involved and led the analyses of some of the largest GWAS in breast cancer conducted by the Breast Cancer Association Consortium and identified more than 100 of the current known polymorphisms that are associated with breast cancer susceptibility. She has co-authored more than 150 publications in high impact journals and is a leading author of publications in Nature, Nature Genetics, Cancer Discovery, American Journal of Human Genetics and others.

Professional website:

https://www.cing.ac.cy/en/about-us/biostatistics_unit/members-of-staff/kyriaki-michailidou

 


 

Download the Fall 2022 EuroCC & SimEA Seminar Series Programme here.

Screenshot 2022 04 12 165256 


 

The EuroCC project has received funding from the European Union’s Horizon 2020 research and innovation programme grant agreement No. 951732

European Union's Horizon 2020 Research and Innovation Programme

The SimEA project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 810660

 


 

The seminar will be in English and the event is open to the public.
This is a hybrid event.  You may attend in-person or alternatively, connect to our live stream of the discussion, available on Zoom (Password: VsSCz1).  If you would like to attend in-person then please RSVP by Monday 3 October, 13:00
Images and/or recordings of our open public events may be used by The Cyprus Institute for dissemination purposes including print and digital media such as websites, press-releases, social media, and live streaming.

 



Contact 
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Additional Info

  • Date: Tuesday, 4 October 2022
  • Time: Starts: 16:00
  • Speaker: Dr Kyriaki Michailidou, Associate Scientist and lead of the Biostatistics Unit, The Cyprus Institute of Neurology and Genetics